• Functionally diverse type V CRISPR-Cas systems

    Functionalities of newly identified type V CRISPR-Cas12 effectors include RNA cleavage and double-stranded DNA nicking.

  • Biology in the bank

    How an open-access trove of data on Britons is unlocking the genetics of disease, behavior, and physical traits.

  • Spotting evolution among us

    The half-million people in the UK Biobank hold the genetic legacy of Neanderthals—and clues to how we are still evolving.

  • Transcriptome-wide isoform-level dysregulation in ASD, schizophrenia, and bipolar disorder

  • Comprehensive functional genomic resource and integrative model for the human brain

  • Neuron-specific signatures in the chromosomal connectome associated with schizophrenia risk

  • Genome-wide de novo risk score implicates promoter variation in autism spectrum disorder

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