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Genetics

  • Modernizing the Modern Synthesis

    Seventy years ago, evolutionary biologists hammered out the modern synthesis to bring Darwin's ideas in line with current insights into how organisms change through time. Some say it's time for Modern Synthesis 2.0.

  • Identifying Autism Loci and Genes by Tracing Recent Shared Ancestry

    A genetic analysis of autism in closely related individuals suggests that defects in proteins that control neural activity may produce this cognitive disorder.

  • X Inactivation Is a Good Thing

    Discussing the medical consequences of X inactivation and effects on individuals with chromosome abnormalities, the author highlights molecular mechanisms for chromosome inactivation and addresses the evolutionary origins of human sex chromosomes.

  • Billion-Dollar Cancer Mapping Project Steps Forward

    Leaders of an ambitious effort to find all common mutations in human cancers delivered their first results to a U.S. government panel last week along with a plain message: Their $100 million pilot is paying off.

  • ‘Biased’ Viruses Suggest New Vaccine Strategy for Polio and Other Diseases

    Introducing hundreds of seemingly inconsequential mutations into a poliovirus can cripple the virus enough to make it work as a live vaccine in mice, scientists report on page 1784 of this week's issue of Science. The technology might lead to safer polio vaccines and perhaps to so-called live attenuated vaccines against other diseases.

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