• Proposal to 'Wikify' GenBank Meets Stiff Resistance

    In a letter in this week's issue of Science, a group of mycologists urges GenBank to allow researchers who discover inaccuracies in the database to append corrections. GenBank, however, says such a fix would cause more problems than it solves.

  • Researchers Hone Their Homology Tools

    How well do homology models, which use solved structures as templates for computer models of the three-dimensional shapes of closely related proteins, work? Not well enough, according to members of a review panel that issued a mixed report card on the Protein Structure Initiative in December.

  • TDP-43 Mutations in Familial and Sporadic Amyotrophic Lateral Sclerosis

    Mutations in a gene that encodes a protein that aggregates in several neurodegenerative disorders are linked to amyotrophic lateral sclerosis (Lou Gehrig’s disease).

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