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Genetics

  • The Man Who Bottled Evolution

    Richard Lenski's 25-year experiment in bacterial evolution shows no signs of running out of surprises about how mutation and selection shape living things.

  • Old Dogs Teach a New Lesson About Canine Origins

    By comparing the mitochondrial genomes of 18 ancient canids with modern dogs, wolves, and coyotes, researchers conclude that dogs were domesticated first in Europe from a lineage of gray wolves that no longer exists.

  • Complete Mitochondrial Genomes of Ancient Canids Suggest a European Origin of Domestic Dogs

    Ancient DNA suggests that dog domestication was complex and likely originated in Europe.

  • Phosphoinositide 3-Kinase δ Gene Mutation Predisposes to Respiratory Infection and Airway Damage

    Gene sequencing of unrelated patients with recurrent airway infections identifies a common underlying mutation. [Also see Perspective by Conley and Fruman]

  • Coordinated Effects of Sequence Variation on DNA Binding, Chromatin Structure, and Transcription

    Human genetic variation results in coordinated allelic variation across molecular phenotypes. [Also see Perspective by Furey and Sethupathy]

  • Identification of Genetic Variants That Affect Histone Modifications in Human Cells

    Human genetic variation affects transcription factor binding, leading to histone modifications. [Also see Perspective by Furey and Sethupathy]

  • Extensive Variation in Chromatin States Across Humans

    Variability among humans with different ancestry affects chromatin states and gene expression. [Also see Perspective by Furey and Sethupathy]

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