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Genetics

  • Integrative Annotation of Variants from 1092 Humans: Application to Cancer Genomics

    Regions under strong selection in the human genome identify noncoding regulatory elements with possible roles in disease.

  • NIH Effort Gambles on Mysterious Extracellular RNAs

    A $17 million research program, announced this month by the U.S. National Institutes of Health, aims to determine whether RNA molecules are deliberately released by cells as hormonelike signals—and whether such extracellular RNAs can be harnessed for diagnosis and treatment of human diseases.

  • Random Sample

    Unlike most organisms, the springtail—a tiny, six-legged noninsect—gets smaller as it gets older, if temperatures are on the rise. And footage from the deep reveals how one deep-sea squid uses its tentacle clubs in an unusual way to lure its prey.

  • The CRISPR Craze

    A bacterial immune system yields a potentially revolutionary genome-editing technique.

  • Mysterious Ribosomopathies

    Ribosomes are essential in all cell types, yet mutations to ribosomal proteins or assembly factors cause tissue-specific disease.

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