• Multiplex Targeted Sequencing Identifies Recurrently Mutated Genes in Autism Spectrum Disorders

    Large-scale human autism candidate gene resequencing implicates de novo mutations in six genes in ~1% of sporadic cases.

  • Areas to Watch

    In 2013, Science's editors will be watching single-cell sequencing, the European Space Agency's Planck satellite, the Human Connectome Project, expeditions to study subglacial Antarctic waters, cancer immunotherapy, and basic plant research.

  • Scorecard: Rating Last Year's Areas to Watch

    The predictions of Science's editors were spot on for this year, involving the long-sought Higgs boson, faster-than-light neutrinos, how metabolism influences the reprogramming of mature cells, whole-genome sequencing, potential targets for reversing cognitive and behavioral symptoms, and the Mars Science Laboratory.

  • The Runners-Up

    A remarkable new method to prepare single strands of ancient DNA and view their genomes topped the list of this year's runners-up for Breakthrough of the Year, along with important discoveries into transcription activator–like effector nucleases, neutrino physics, Majorana fermions, the production of eggs cells from stem cells, and brain-machine interfaces. Other notable advances involve the Encyclopedia of DNA Elements, the Mars Curiosity rover, and the use of x-ray lasers to determine protein structure.

  • Beyond TALENs

    Zinc finger nucleases and TALENS are not the only up-and-coming genome engineering tools. There are meganucleases that are DNA-cutting enzymes encoded by certain mobile elements, nucleases that might do the job solo, and a potential bacterial defense system.

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