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Genetics

  • An Expressed Fgf4 Retrogene Is Associated with Breed-Defining Chondrodysplasia in Domestic Dogs

    The short legs that characterize certain dog breeds are associated with a gene that arose recently by RNA-based gene duplication.

  • Recipe for Induced Pluripotent Stem Cells Just Got Clearer

    A clutch of five letters published online this week shows that p53 hinders the generation of induced pluripotent stem (iPS) cells. The work suggests ways to control the formation of iPS cells, although that capability will have to be used judiciously because p53 helps ensure the fitness of generated cells.

  • Epigenetic Determinism

    Discussing both their hopes and reservations, the McCabes highlight ethical issues while conveying the potential of genomic medicine.

  • The Genetic Architecture of Maize Flowering Time

    Assaying nearly one million plants reveals that maize flowering time is not controlled by a large effect at any single locus.

  • Genetic Properties of the Maize Nested Association Mapping Population

    Outcrossing vigor in maize is most likely due to retained variability in regions around the centromeres.

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