• Recipe for Induced Pluripotent Stem Cells Just Got Clearer

    A clutch of five letters published online this week shows that p53 hinders the generation of induced pluripotent stem (iPS) cells. The work suggests ways to control the formation of iPS cells, although that capability will have to be used judiciously because p53 helps ensure the fitness of generated cells.

  • Epigenetic Determinism

    Discussing both their hopes and reservations, the McCabes highlight ethical issues while conveying the potential of genomic medicine.

  • The Genetic Architecture of Maize Flowering Time

    Assaying nearly one million plants reveals that maize flowering time is not controlled by a large effect at any single locus.

  • A-maize-ing Diversity

    Analysis of a new maize resource reveals that a large number of genetic loci with small effects may underlie the wide variation seen in traits such as flowering time.

  • Genetic Properties of the Maize Nested Association Mapping Population

    Outcrossing vigor in maize is most likely due to retained variability in regions around the centromeres.

  • Plant Bar Code Soon to Become Reality

    A paper published this week in the Proceedings of the National Academy of Sciences proposes two genetic sequences, or loci, taken from chloroplast genes called matK and rbcL, as the official plant "bar code," a short piece of DNA that can be used to distinguish species.

  • From Science's Online Daily News Site

    Highlights from Science's online daily news site, ScienceNOW, this week include exploding raindrops, no risk in disclosing genetic risks, an ancient climate-change puzzle, and elephants that don't always keep it in the family.

  • Knockout Rats via Embryo Microinjection of Zinc-Finger Nucleases

    Targeted gene disruption in rats paves the way for new human disease models.

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