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Microbiology

  • Invertible promoters mediate bacterial phase variation, antibiotic resistance, and host adaptation in the gut

    Phase variation prepares host-associated bacteria for sudden environmental change, including antibiotic exposure.

  • Metagenomic sequencing at the epicenter of the Nigeria 2018 Lassa fever outbreak

    Mobile nanopore sequencing technology has been successfully used for direct sequencing from hemorrhagic fever patient samples.

  • Salmonella persisters undermine host immune defenses during antibiotic treatment

    Antibiotic-tolerant, nongrowing Salmonella persister cells modulate the host cell environment to ensure regrowth upon antibiotic removal.

  • Open-source discovery of chemical leads for next-generation chemoprotective antimalarials

    Screening of more than half a million compounds for their ability to inhibit liver-stage Plasmodium development yields thousands of candidates.

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