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INHIBITION OF β HEMOLYTIC STREPTOCOCCI FIBRINOLYSIN BY TRYPSIN INHIBITOR (ANTIPROTEASE)

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Science  01 Sep 1944:
Vol. 100, Issue 2592, pp. 198-200
DOI: 10.1126/science.100.2592.198

Abstract

Crystalline "trypsin-inhibitor" of pancreatic origin and the antitrypsin of soybean origin completely inhibit the fibrinolytic activity of cultures of β hemolytic streptococci, of filtrates of such cultures and of concentrates of such filtrates. It is suggested that the streptococcal fibrinolysin is a protease and that it may be related to trypsin.

The author wishes to acknowledge gratefully the cooperation of Lieutenant Colonel Robert L. King, Lieutenant Colonel E. D. Embree and Captain Edward Freis.