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TELANG LIVER AND VITAMIN A TOXICITY

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Science  13 Oct 1944:
Vol. 100, Issue 2598, pp. 338-339
DOI: 10.1126/science.100.2598.338

Abstract

(1) About 20 per cent. of fresh telang livers were toxic to weanling rats receiving the calcium supplemented livers as their sole dietary.

(2) The symptoms observed in rats were growth failure and multiple spontaneous fractures of the bones of the extremities.

(3) The toxicity of certain telang livers was due to their abnormally high stores of vitamin A. When these livers, supplemented only with calcium carbonate, were fed to weanling rats, the daily intake of vitamin A was in excess of the toxic dosage of 15,000 I.U. per day.

(4) Identical symptoms of toxicity were observed in weanling rats fed 20,000 I.U. of crystalline vitamin A per day in conjunction with a standard stock ration.