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THE ANTIBACTERIAL ACTION OF PENICILLIN AGAINST GRAM NEGATIVE ORGANISMS

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Science  01 Dec 1944:
Vol. 100, Issue 2605, pp. 500-501
DOI: 10.1126/science.100.2605.500

Abstract

It is apparent that penicillin exerts an antibacterial action against Gram negative as well as Gram positive organisms. This property of penicillin becomes more apparent in high potency preparations. It is possible that a form of penicillin showing greater activity against Gram negative organisms may exist. Studies on the nature of such a substance and on the in vivo action of penicillin against Gram negative organisms are in progress.