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INTERACTION BETWEEN CRYSTALLINE PENICILLIN AND HUMAN PLASMA PROTEINS

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Science  19 Jan 1945:
Vol. 101, Issue 2612, pp. 67-68
DOI: 10.1126/science.101.2612.67

Abstract

Penicillin combines with human serum albumin, as demonstrated by dialysis experiments. Unlike the sulfonamfide-albumin complex, the penicillin-albumin possesses antibiotic activity. Such a complex can be freed of unbound penicillin by repeated precipitation at 50 per cent. alcohol and obtained as a dried powder. Mouse excretion studies indicated that the penicillin-albumin complex was excreted more slowly than the sodium salt of penicillin.