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MAINTENANCE OF THE BLOOD LEVEL OF PENICILLIN AFTER INTRAMUSCULAR INJECTION

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Science  23 Feb 1945:
Vol. 101, Issue 2617, pp. 203-205
DOI: 10.1126/science.101.2617.203

Abstract

Blood concentrations of penicillin were maintained at measurable levels for as long as seven or eight hours following single intramuscular injections of penicillin in the dog and in patients by means of vehicles containing 6 per cent. to 20 per cent. ossein gelatin and a long-acting vasoconstrictor drug.

Intramuscular administration of penicillin can thus be carried on with three instead of eight injections per day with less variation in the extremes of penicillin blood levels.

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