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Science  02 Mar 1945:
Vol. 101, Issue 2618, pp. 228-229
DOI: 10.1126/science.101.2618.228


It is possible to attain serum concentrations of penicillin after oral administration comparable to those attained after intramuscular injection by the use of approximately five times as much penicillin. As the concentrations attained following the ingestion of penicillin by four different methods were all of the same order of magnitude, it would seem that the present problem in oral administration is analogous to that with intramuscular administration, i.e., to find the ideal vehicle whereby the duration of the serum concentration can be prolonged.