ArticlesSpecial Article

ORAL ADMINISTRATION OF PENICILLIN

Science  07 Sep 1945:
Vol. 102, Issue 2645, pp. 247-250
DOI: 10.1126/science.102.2645.247

Abstract

A convenient, practical and effective procedure of administering penicillin by mouth consists of mixing the drug with one tablespoonful of aluminum hydroxide. Substantially higher blood levels are obtained following a 50,000 and a 100,000 unit dose of penicillin with this method than after administration of the drug dissolved in water, either with or without previous ingestion of a mild antacid, such as aluminum hydroxide. Adsorption of penicillin on aluminum hydroxide appears to exert a local protective effect against that portion of gastric acid with which it comes into contact.

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