ArticlesSpecial Article

SUSCEPTIBILITY OF THE YOUNG WHITE MOUSE (MUS MUSCULUS) TO EXPERIMENTAL LEPTOSPIROSIS

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Science  05 Oct 1945:
Vol. 102, Issue 2649, pp. 352-353
DOI: 10.1126/science.102.2649.352

Abstract

The failure of even special methods to induce infection indicates that not all strains of young white laboratory mice (Mus musculus) are uniformly susceptible to fatal infection with Leptospira icterohemorrhagiae. Some strains of this species develop early pathological changes characteristic of the infection and harbor the organism in their kidneys, but do not succumb. Therefore not all strains of white mice are suitable for use in the diagnostic mouse protection test for leptospirosis described by Larson.