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HEATED, AVIRULENT ANTIGENS FOR COMPLEMENT-FIXATION TESTS WITH CERTAIN ENCEPHALITIS VIRUSES

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Science  14 Dec 1945:
Vol. 102, Issue 2659, pp. 618-619
DOI: 10.1126/science.102.2659.618

Abstract

A simple method is described for producing avirulent mouse brain antigens for complement-fixation tests in human encephalitides, by application of heat at 60° C for 30 minutes. The heated antigens retain for most of the viruses employed a sufficiently high titer to warrant their use, since they are also specific, not anticomplementary, can be lyophilized and moreover, are avirulent, and thus can be handled with safety.

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