Technical Papers

Studies on the Toxicity of Streptomycin for Man: A Preliminary Report

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Science  22 Mar 1946:
Vol. 103, Issue 2673, pp. 355-357
DOI: 10.1126/science.103.2673.355

Abstract

In this limited experience, tests of renal and hepatic function together with blood studies before and after the parenteral administration of streptomycin revealed no evidence of serious toxicity. Reactions, consisting of fever, arthralgias, and skin rashes as well as histamine-like effects, are believed to be due to impurities retained in the preparations of streptomycin employed in these studies.