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Some Physical and Biologic Properties of Subtilin and Other Antibiotics

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Science  05 Apr 1946:
Vol. 103, Issue 2675, pp. 419-420
DOI: 10.1126/science.103.2675.419


Subtilin, a new antibiotic obtained from B. subtilis, proved active in vitro against L. plantarum, E. histolytica and its associated bacterium `t', and T. equiperdum without causing immediate hemolysis of erythrocytes. Subtilin is tensioactive, and amounts required for antibiotic effect are within the range of surface tension activity. It was relatively nontoxic for four species of mammals, especially after intragastric administration. Gramicidin is more hemolytic and more toxic than subtilin.