Technical Papers

Inactivation of Penicillins G and K by Liver and Kidney

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Science  03 Jan 1947:
Vol. 105, Issue 2714, pp. 18-19
DOI: 10.1126/science.105.2714.18


The inactivation of penicillin K is more rapid in the renal-ligated rabbit than in the renal-ligated, eviscerate preparation. Inactivation of penicillin K occurs in the presence of surviving liver and kidney slices. Small amounts of penicillin G were inactivated by liver slices; larger amounts disappeared in the presence of kidney slices. The inactivation of penicillin K in the presence of rabbit liver and kidney slices is demonstrable anaerobically as well as aerobically.