ArticlesIn the Laboratory

Autolyzed Brain Tissue as a Means of Facilitating Transmission of Experimental Poliomyelitis

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Science  17 Jan 1947:
Vol. 105, Issue 2716, pp. 70-72
DOI: 10.1126/science.105.2716.70-a


Autolyzed brain tissue diluent shortens the incubation period and facilitates the transfer of poliomyelitis virus to CFW Swiss mice, hamsters, and rhesus monkeys. The Leon monkey-passage strain of poliomyelitis virus was successfully adapted to CFW Swiss mice by means of this technic.

Since this manuscript was submitted we have isolated several strains of poliomyelitis virus from infected human feces and spinal cord in CFW Swiss mice by means of this technic.