Reports

O-methylation, the Principal Route of Metabolism of Epinephrine in Man

Science  12 Sep 1958:
Vol. 128, Issue 3324, pp. 593-594
DOI: 10.1126/science.128.3324.593

Abstract

Evidence is presented which indicates that the principal pathway of metabolism of epinephrine in man is O-methylation to metanephrine. The extent of the conLversion to metanephrine, a physiologically inactive compound, indicates that the enzyme responsible for this reaction, catechol-O-methyl transferase, is the enzyme mainly involved in the termination of action of epinephrine in man.

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