O-methylation, the Principal Route of Metabolism of Epinephrine in Man

See allHide authors and affiliations

Science  12 Sep 1958:
Vol. 128, Issue 3324, pp. 593-594
DOI: 10.1126/science.128.3324.593


Evidence is presented which indicates that the principal pathway of metabolism of epinephrine in man is O-methylation to metanephrine. The extent of the conLversion to metanephrine, a physiologically inactive compound, indicates that the enzyme responsible for this reaction, catechol-O-methyl transferase, is the enzyme mainly involved in the termination of action of epinephrine in man.