Evidence That the Mammalian Nephron Functions as a Countercurrent Multiplier System

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Science  12 Sep 1958:
Vol. 128, Issue 3324, pp. 594
DOI: 10.1126/science.128.3324.594


Fluid collected by micropuncture from the bend of the loop of Henle in the concentrating hamster kidney had the same osmotic pressure as fluid from a collecting duct at the same level, while that from the distal convolution was more dilute. This indicates that the tubular fluid is first concentrated, then diluted, before its final concentration.