Tranquilizing and Antiserotonin Activity of Nicotinamide

Science  21 Nov 1958:
Vol. 128, Issue 3334, pp. 1277-1278
DOI: 10.1126/science.128.3334.1277


Nicotinamide in large amounts antagonized the action of serotonin on smooth muscles in vitro and in vivo. It also tranquilized animals. The antagonism differed in some respects from that of an antimetabolite of serotonin.