Demethylation of Chlorpromazine-(N-Methyl)-C14

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Science  21 Nov 1958:
Vol. 128, Issue 3334, pp. 1279-1280
DOI: 10.1126/science.128.3334.1279


Chlorpromazine methyl-C14 was administered to three groups of rats—orally to one group following chronic oral administration of the unlabeled drug; orally to an unprimed group; and intravenously to another unprimed group. Appearance of C14O2 in the air expired by all animals indicated that the rat metabolized the side chain of the labeled drug.