Occurrence of Lithocholic Acid in Feces of Healthy Men

See allHide authors and affiliations

Science  05 Dec 1958:
Vol. 128, Issue 3336, pp. 1433-1434
DOI: 10.1126/science.128.3336.1433


Crystalline lithocholic (3α-hydroxycholanic) acid was isolated from a pooled sample of feces from healthy men for the first time. This acid, which occurs in small amounts in human bile, was obtained by alcohol extraction, followed by solvent partition and chromatography. Under these conditions most of the acid was recovered in the form of its methyl ester.