Effects of Magnesium and Tetraethylammonium Chloride on the Hypothermic Heart

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Science  05 Dec 1958:
Vol. 128, Issue 3336, pp. 1435
DOI: 10.1126/science.128.3336.1435


Ventricular fibrillation was induced by the injection of magnesium chloride in isolated canine hearts as well as in intact animals. Ventricular magnesium tolerance was greatly reduced during hypothermia. Defibrillation was achieved by intracoronary injection of tetraethylammonium chloride and electrical shock, even at temperatures as low as 21°C, where it could not be achieved by other means.