Inhibition of Enzymatic Synthesis of Pantothenate by 2,3-Dichloroisobutyrate

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Science  12 Dec 1958:
Vol. 128, Issue 3337, pp. 1509-1510
DOI: 10.1126/science.128.3337.1509


The investigations reported here have shown that 2,3-dichloroisobuty-rate is uncompetitive with β-alanine and competitive with pantoate for a site on the enzyme of pantothenate synthesis. The enzyme dissociation constant of the inhibitor was comparable to that of the competitive substrate.