Correlation of Drug Penetration of Brain and Chemical Structure

Science  19 Dec 1958:
Vol. 128, Issue 3338, pp. 1572-1574
DOI: 10.1126/science.128.3338.1572-a


A study has been carried out on the permeability of the brain and a brain tumor to certain aromatic boronic acids with regard to their use in the neutron capture therapy of gliomas. The penetration of the brain by these compounds is discussed as a function of chemical substituent and benzene-aqueous partition coefficient.