Newly Found Action of Cocaine

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Science  16 Jan 1959:
Vol. 129, Issue 3342, pp. 151-152
DOI: 10.1126/science.129.3342.151


Cocaine augments appreciably the effects of small doses of acetylcholine on the heart rate, blood pressure, and the nictitating membrane in intact, anesthetized animals. This phenomenon assigns cocaine, thus far only known as a potentiator of adrenergic stimulation, a more general role of potentiator of both adrenergic and cholinergic neurohumors.