Possible Biochemical Implications of the Crystal Structure of Biotin

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Science  23 Jan 1959:
Vol. 129, Issue 3343, pp. 210
DOI: 10.1126/science.129.3343.210


An examination of the molecular architecture of biotin, as determined by x-ray crystallographic analysis, has indicated that biotin may be capable of forming an intramolecular hydrogen bond in solution. A review of various chemical analogs of the vitamin has shown a close correlation between the possibility of forming such a hydrogen bond and biotin-like activity.