Fibrillation and Potassium Influx

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Science  23 Jan 1959:
Vol. 129, Issue 3343, pp. 212
DOI: 10.1126/science.129.3343.212


Absolute influx and efflux of potassium-42 have been measured in isolated rabbit atria during acetylcholine-induced fibrillation. The efflux of potassium was increased three to four times; influx was not changed. The data are interpreted as indicating that an inhibition of active K uptake is not involved in the initiation of fibrillation, and that the process results from a marked increase in Na permeability.