Failure of Nicotine to Affect Development of Offspring When Administered to Pregnant Rats

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Science  23 Jan 1959:
Vol. 129, Issue 3343, pp. 212-214
DOI: 10.1126/science.129.3343.212-a


Administration of nicotine to rats at any point in pregnancy has no apparent effect upon completion or duration of pregnancy, or upon body development, litter size, weight, or mortality of offspring. These results differ sharply from the effects in mice reported by others. The possible etiologic significance of anoxia in the malformations reported in mice is discussed.