Significance of Mitochondria for Porphyrin and Heme Biosynthesis

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Science  30 Jan 1959:
Vol. 129, Issue 3344, pp. 275-276
DOI: 10.1126/science.129.3344.275


It is concluded that mitochondria are involved in three steps of porphyrin and heme biosynthesis—first, in the formation of δ-aminolevulinic acid from glycine and active succinate; second, in the synthesis of protoporphyrin; third, in the incorporation of iron into the porphyrin ring—that is, in heme formation.