Biliary Excretion by the Rat of Bromsulfalein as a Conjugate of Glycine and Glutamic Acid

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Science  13 Feb 1959:
Vol. 129, Issue 3346, pp. 388-389
DOI: 10.1126/science.129.3346.388


Paper chromatograms of bile collected after the intravenous administration of bromsulfalein to rats reveal four distinct bromsulfalein bands. One migrates with the same Rf as standard bromsulfalein; the other three move less fast. The major band, which accounts for 71.3 percent of the injected bromsulfalein, appears to be a conjugate of bromsulfalein with glycine and glutamic acid.