Aggregate Replication, a Factor in the Growth of Cancer

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Science  20 Feb 1959:
Vol. 129, Issue 3347, pp. 466-467
DOI: 10.1126/science.129.3347.466


Microscopically, most clinical carcinomas appear as aggregates of neoplastic cells in a matrix of connective tissue. As the tumor grows, increasing numbers of nests of cells are seen. Studies in which matrix tissue culture techniques are used implicate factors intrinsic to the aggregate in the continuing propagation of new nests of cells.