Cholecystokinin Activity of Urine

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Science  27 Feb 1959:
Vol. 129, Issue 3348, pp. 567-568
DOI: 10.1126/science.129.3348.567


In the urine of men and animals was found a factor which evokes the contraction of the gall bladder. This factor increases in the urine after the application of a secretogenous stimulus to the duodenum and decreases after resection of the duodenum. A urine concentrate was prepared which has an effect similar to that of cholecystokinin administered intravenously and which was therefore called urocholecystokinin.