Bromination of Phenol Red by the Dogfish, Squalus acanthias

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Science  20 Mar 1959:
Vol. 129, Issue 3351, pp. 778-779
DOI: 10.1126/science.129.3351.778


The uterus of the pregnant spiny dogfish, Squalus acanthias, can convert phenol red into a new purplish-blue dye. Evidence shows that the new dye is bromophenol blue. This is the first example of biological bromination that has been observed in a vertebrate.