Use of an Organic Carbon Dioxide Buffer in vivo

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Science  20 Mar 1959:
Vol. 129, Issue 3351, pp. 782-783
DOI: 10.1126/science.129.3351.782


The compound 2-amino-2(hydroxymethyl)1,3-propane diol was administered intravenously to apneically oxygenated dogs over a 1-hour period. Arterial blood pH remained normal, and an estimated 18 to 28 percent of the CO2 produced during apnea was recovered in the urine.