Role of Myocardial Catecholamines in Cardiac Contractility

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Science  10 Apr 1959:
Vol. 129, Issue 3354, pp. 967-968
DOI: 10.1126/science.129.3354.967


In cats bilateral sympathectomy or administration of reserpine results in a marked reduction in concentration of myocardial catecholamines. The contractility of papillary muscles from such animals is significantly less than that of muscles from untreated animals. These findings demonstrate the importance of normal levels of myocardial catecholamines in the maintenance of normal cardiac contractility.