Interference with Feedback Control: a Mechanism of Antimetabolite Action

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Science  10 Apr 1959:
Vol. 129, Issue 3354, pp. 968-969
DOI: 10.1126/science.129.3354.968


The action of an enzyme essential for tryptophan biosynthesis is inhibited by tryptophan and also by an analog of tryptophan. Similarly, histidine and one of its analogs inhibit the action of an enzyme essential for histidine biosynthesis. A mutant resistant to the histidine analog produces an apparently altered enzyme which is insensitive to both the analog and histidine.