Factors Contributing to Production of "Virus-Free" Tumors in Turkeys by Rous Sarcoma Virus

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Science  17 Apr 1959:
Vol. 129, Issue 3355, pp. 1022-1023
DOI: 10.1126/science.129.3355.1022


Virus-neutralizing factors in tumor extracts and sera, age of the tumor, and the infecting dose of virus are important factors contributing to the infective titer of tumor tissue. Tumors produced with small amounts of virus may contain no demonstrable infective virus, and detectable inhibitory factors may or may not be present in tumor extracts or sera.