Development of a Chick Embryo Heart Cell for the Cultivation of Poliovirus

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Science  17 Apr 1959:
Vol. 129, Issue 3355, pp. 1025-1026
DOI: 10.1126/science.129.3355.1025


An epithelial-like cell has been developed in line culture that apparently is stable. Although initially isolated cells were incapable of supporting the growth of poliovirus, the cells of the sixth and later passages allowed virus to propagate. The early, nonsusceptible cells were fibroblastic in appearance, in contrast to the epithelial type, poliovirussusceptible, derived cell of later passages.