Paradoxical Action of Solvents on Bacterial and Liver β-Glucuronidases

Science  08 May 1959:
Vol. 129, Issue 3358, pp. 1281
DOI: 10.1126/science.129.3358.1281


Dichloromethane and chloroform have been found to inhibit the action of liver β-glucuronidase on phenolphthalein glucuronic acid at concentrations which produce a considerable enhancement of bacterial β-glucuronidase. Other solvents, including n-butanol, benzene, and toluene, have very little effect on the liver enzyme but nevertheless potentiate the bacterial enzyme.