Carotenogenesis and Resistance of Micrococcus pyogenes to Tetracyclines

See allHide authors and affiliations

Science  15 May 1959:
Vol. 129, Issue 3359, pp. 1359-1360
DOI: 10.1126/science.129.3359.1359-a


Although reddish-yellow pigments, mainly §-carotene and rubixanthine, were present in the original strain of Micrococcus pyogenes var. aureus, mutants highly resistant to tetracyclines were observed to become colorless. All strains lack lipoxidase activity. The colorless strains probably reflect blocking by tetracyclines during carotenogenesis.