Nucleoprotein Constituents Stimulating Growth in Tissue Culture: Active Protein Fraction

Science  29 May 1959:
Vol. 129, Issue 3361, pp. 1486-1487
DOI: 10.1126/science.129.3361.1486


A new method has been developed for removing the nucleic acid portion of the nucleoprotein fraction which stimulates growth in tissue culture. Biological activity resides in the purified protein fraction, while the high-polymer nucleic acid fraction is inert. The active protein fraction contains extractable lipids which have no effect on the biological activity.