Phenylpyruvic Acid as a Possible Precursor of o-Hydroxyphenylacetic Acid in Man

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Science  05 Jun 1959:
Vol. 129, Issue 3362, pp. 1553
DOI: 10.1126/science.129.3362.1553


The oral administration of phenylpyruvic acid to human subjects results in increased urinary excretion of o-hydroxyphenylacetic acid. This demonstrates that phenylpyruvic acid may act as a precursor for o-hydroxy derivatives of phenylalanine and suggests that the formation of o-tyrosine is not necessary to account for the excretion of o-hydroxyphenylacetic acid in phenylketonuria.