Interaction of Curare and Related Substances with Acetylcholine Receptor-Like Protein

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Science  12 Jun 1959:
Vol. 129, Issue 3363, pp. 1613-1614
DOI: 10.1126/science.129.3363.1613


Existence of a receptor protein for acetylcholine has been postulated, and the hypothesis has been supported by experiments in intact cells. A protein from electric tissue has now been obtained in solution; there is striking parallelism between the ability of this protein to bind acetylcholine analogs and the effects of such analogs on electrical manifestations of intact electroplax.