Reports

Enzymatic Activity of a Genetically Altered Tryptophan Synthetase in Neurospora crassa

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Science  12 Jun 1959:
Vol. 129, Issue 3363, pp. 1614-1615
DOI: 10.1126/science.129.3363.1614

Abstract

Partially purified preparations of certain tryptophan-requiring mutants of Neurospora crassa, which contain a protein (CRM) antigenically related to wild-type tryptophan synthetase, possess indole glycerol phosphate-synthesizing activity. This activity can be inhibited by anti-CRM sera. It is suggested that CRM in such mutants represents a damaged tryptophan synthetase lacking the capacity to react with l-serine.

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